The “Botox Alternative” Peptide for Visible Wrinkle Reduction

ZLEY®PP201 – Acetyl Hexapeptide-8 (CAS 616204-22-9):

The “Botox Alternative” Peptide for Visible Wrinkle Reduction

Aperçu du produit

ZLEY®PP201–Acetyl Hexapeptide-8, also known as Argireline ou “Botox in a bottle,” is a premium anti-wrinkle cosmetic peptide widely used in high-end skincare formulations. It is a synthetic peptide composed of six amino acids (Ac-EEMQRR-NH₂) that mimics the N-terminal end of the SNAP-25 protein.

By locally blocking neuromuscular transmission signals, Acetyl Hexapeptide-8 relaxes facial muscles, smoothing expression lines (dynamic wrinkles), static wrinkles, and fine lines. It also helps reorganize collagen synthesis and improve elastin activity. The result is visible wrinkle reduction and a more rested, youthful facial appearance—without injections.

ZLEY® est un fournisseur professionnel de cette matière première, garantissant une qualité constante, une assistance technique et des services de livraison à l'échelle mondiale couvrant plus de 60 pays.

ZLEY®PP201–Acetyl Hexapeptide-8 Informations sur le produit

Est ZLEY®PP201–Acetyl Hexapeptide-8 Sûr?

Oui. Acetyl Hexapeptide-8 has a well-established safety profile in cosmetic applications.

When used within recommended concentrations, ZLEY®PP201–Acetyl Hexapeptide-8 does not pose a risk to human health under normal, reasonable, and foreseeable conditions of use.

Mécanisme d'action

• ZLEY®PP201–Acetyl Hexapeptide-8 (Acetyl Hexapeptide-8) functions as a neurotransmitter inhibitory peptide (NIP) through the following mechanism:
• SNARE Complex Inhibition: Acetyl Hexapeptide-8 mimics the N-terminal end of the SNAP-25 protein, competing with SNAP-25 for a position in the SNARE complex.
• Reduced Neurotransmitter Release: If the SNARE complex is destabilized, synaptic vesicles cannot efficiently release neurotransmitters (acetylcholine) at the neuromuscular junction.
• Muscle Relaxation: Weakened muscle contraction signals reduce facial muscle tension, preventing the formation of expression lines and smoothing existing wrinkles.
• Collagen & Elastin Support: The peptide also helps reorganize collagen elasticity and increase elastin activity, improving skin firmness and reducing laxity.

This dual-action mechanism—muscle relaxation plus structural support—makes Acetyl Hexapeptide-8 a comprehensive anti-wrinkle solution that does not require injections.

Applications des produits

ZLEY®PP201–Acetyl Hexapeptide-8 is a water-soluble, highly effective active ingredient suitable for a wide range of anti-wrinkle and anti-aging formulations:

It is particularly effective for areas with high muscle activity, such as the forehead, around the eyes, and the face in general.

Pourquoi Source ? ZLEY®PP201–Acetyl Hexapeptide-8 de ZLEY® ?

Forte de plus de 20 ans d’expérience dans les domaines de la R&D, de la production, du contrôle qualité et de la commercialisation, ZLEY® s’engage à fournir des matières premières haut de gamme destinées aux soins personnels ainsi que des solutions sur mesure. Notre réseau de distribution mondial dessert des clients dans plus de 60 pays.

Courriel : [email protected]

Foire aux questions (FAQ)

Q1: What is Acetyl Hexapeptide-8 (Argireline)?

A: Acetyl Hexapeptide-8, also known as Argireline, is a synthetic peptide that mimics the N-terminal end of the SNAP-25 protein. It is widely used in cosmetics as topical, non‑injectable alternative to Botox for reducing expression lines and wrinkles.

Q2: How does it work to reduce wrinkles?

A: It works by competitively inhibiting the SNARE complex, which reduces the release of acetylcholine at the neuromuscular junction. This weakens muscle contractions, preventing the formation of dynamic wrinkles and smoothing existing lines.

Q3 : Quelle est la dose d'utilisation recommandée ?

R : La plage d'utilisation recommandée est de 0.01%–0.05% for the active peptide powder. The CIR has assessed it as safe at concentrations up to 0.005%. At these levels, it delivers effective anti-wrinkle benefits with minimal risk of side effects.

Q4: What product types is it suitable for?

A: It is suitable for serums, creams, masks, eye contour products, and other anti-wrinkle formulations. It is particularly effective for areas with high muscle activity such as the forehead and around the eyes.

Q5: How should ZLEY®PP201–Acetyl Hexapeptide-8 be incorporated into formulations?

A: Due to its excellent water solubility, it can be added directly to the water phase at temperatures below 40°C, preferably during the final stage of production.