ZLEY® QUATERNIUM-73-001 (CAS 15763-48-1):
The Star OTC Acne Fighter from Japan

ZLEY® QUATERNIUM-73 is commonly used in Japanese over-the-counter (OTC) products as an anti-acne ingredient. It possesses extremely potent antimicrobial activity by disrupting bacterial and fungal cell membranes, and demonstrates excellent efficacy against Propionibacterium acnes. Additionally, it inhibits melanin formation. This combination of high efficacy and excellent safety makes it a popular choice for acne treatment and brightening/spot-correcting products.
ZLEY Group is a professional supplier of ZLEY® QUATERNIUM-73 (CAS 15763-48-1), providing stable quality, technical support, and global delivery services, covering over 60 countries. For specifications, samples, or quotations, please contact [email protected]
Product Information: ZLEY® QUATERNIUM-73
Also Known As: Pierre-Ning
CAS No.: 15763-48-1
Safety Risk: Level 1, Green (Source: Beauty Evolution)
Carcinogenic Risk: None (Source: Beauty Evolution)
Product Efficacy: Antibacterial, Anti-acne, Brightening
Appearance: Yellow powder or crystals
Recommended Dosage: 0.001% ~ 0.05%
Solubility: Alcohol-soluble
Processing Instructions: Pre-dissolve in alcohol before adding to the formulation.
Precautions: Store away from light.
Is ZLEY® QUATERNIUM-73 Safe?
Yes. When used in cosmetics, the recommended maximum concentrations for ZLEY® QUATERNIUM-73 are:
0.05% in leave-on products for the whole body.
1% in leave-on products for the face (including neck).
0.1% in leave-on products for the eye area.
For other application areas: torso (leave-on) can refer to the whole body limit of 0.05%; hands, feet, scalp, hair, and lips can refer to the face/neck limit of 1%; nails can refer to the eye area limit of 0.1%. Under normal, reasonable, and foreseeable conditions of use, it poses no potential harm to human health.
Product Applications of ZLEY® QUATERNIUM-73
Acts as an antibacterial agent and inhibitor for comedones and acne.
Can be used as a preservative with strong biocidal activity against bacteria, Staphylococcus, E. coli, etc., outperforming parabens. It also inhibits melanin production.
Clinical studies show its MIC (Minimum Inhibitory Concentration) against Propionibacterium acnes is 0.00002%, and it can reduce acne lesions by 50% after two weeks of use. At a concentration of 0.1 ppm, it completely inhibits melanin formation, surpassing the performance of kojic acid.
High safety profile, good thermal stability, stable within a pH range of 5.5 to 8.0. Low usage level offers high cost-effectiveness.
Why Source ZLEY® QUATERNIUM-73 from ZLEY Group?
Through over 20 years of relentless effort, ZLEY Group has become a modern enterprise integrating R&D, production, quality control, and sales. We are dedicated to providing clients with the highest quality personal care ingredients, semi-finished products, and customized formulation solutions to meet diverse needs, ensuring the best products and services. Email:[email protected]
What Technical Support Can You Get When Sourcing ZLEY® QUATERNIUM-73?
As a professional supplier, ZLEY Group offers value beyond the product itself:
Formulation Support: Provides basic formula suggestions, combination strategies, and process guidance.
Regulatory Consulting: Assists in interpreting the regulatory requirements of target markets.
Quality & Supply Assurance: Stable product quality, competitive pricing, and reliable global logistics.
Market Trend Information: Shares the latest market dynamics and ingredient application trends.
Technical Specifications of ZLEY® QUATERNIUM-73

Frequently Asked Questions (FAQ) about ZLEY® QUATERNIUM-73
Q1: What is the recommended dosage of ZLEY® QUATERNIUM-73 in formulations, and are there regulatory limits?
Recommended Dosage: 0.1% – 1.0% (in the final product).
Key Market Limits: The maximum allowed concentration is 0.5% in both China and the EU (in the final product). Always verify the latest regulations in your target country.
Q2: Can ZLEY® QUATERNIUM-73 be combined with other anti-dandruff agents (e.g., OCT, Salicylic Acid)? How is the effect?
Yes, and combining often yields better results.
With Piroctone Olamine: Synergistic effect.
With Salicylic Acid: Exfoliation + antibacterial action, addressing both symptoms and root cause.
With Soothing Botanical Extracts: Enhances gentleness.
Q3: How can I obtain samples, technical documents, and quotations?
Please contact our international trade service team via [email protected] We will provide a professional and efficient response. Please include your company information, specific needs, and target market in your email for the most precise assistance.
