ZLEY® Gluconolactone (CAS 90-80-2):
The “Second-Generation AHA” – Gentle Enough for Sensitive Skin
Product Overview
Gluconolactone, also known as the “second-generation alpha-hydroxy acid (AHA)” is an ester formed by the dehydration of gluconic acid’s carboxyl group with its intramolecular hydroxyl group. It belongs to the class of polyhydroxy acids (PHAs).
Compared to first-generation AHAs (such as glycolic acid and salicylic acid), which penetrate deeply and can be irritating, gluconolactone has a larger molecular weight, resulting in slower, more gradual skin penetration and significantly lower irritation. It works by hydrolyzing to gluconic acid on the skin, reducing the adhesion between corneocytes and promoting the gentle shedding of dead skin cells. Additionally, its four hydrophilic groups provide superior water-binding capacity, delivering excellent moisturizing benefits.
ZLEY® is a professional supplier of Gluconolactone (CAS 90-80-2), providing stable quality, technical support, and global delivery covering over 60 countries.
ZLEY® Gluconolactone Product Information
Is ZLEY® Gluconolactone Safe?
Yes. According to the final report from the U.S. Cosmetic Ingredient Review (CIR), gluconolactone is considered safe for use in cosmetic products at concentrations up to 15% in leave-on products and 0.3% in rinse-off products . The ingredient is listed in China’s “Inventory of Existing Cosmetic Ingredients (2021 Edition)” with a maximum historical use level of 15% in leave-on products . Under normal, reasonable, and foreseeable conditions of use, it does not pose a risk to human health.
Product Applications
Gluconolactone, known as the “second-generation AHA” , is a gentle skincare ingredient offering multiple benefits including moisturizing, exfoliation, and skin barrier enhancement . Its mild nature makes it suitable for sensitive skin and for use in combination with other active ingredients such as retinoic acid .
Key applications include:
Why Source ZLEY® Gluconolactone from ZLEY®?
With over 20 years of dedicated experience, ZLEY® has evolved into a modern enterprise integrating research, production, quality control, and sales. We are committed to providing the highest quality personal care raw materials, semi-finished products, and customized formulation solutions to meet diverse customer needs. Our global delivery network ensures reliable service to customers in over 60 countries.
Email: [email protected]
What Technical Support Can You Expect?
As a specialized supplier, ZLEY® offers value beyond the product itself:
- Formulation Support: Basic formulation recommendations, combination suggestions, and processing guidance
- Regulatory Consulting: Assistance with interpreting compliance requirements for target markets
- Quality Assurance: Consistent quality, competitive pricing, and reliable global logistics
- Market Intelligence: Latest market trends and ingredient application insights
ZLEY® Gluconolactone – Frequently Asked Questions (FAQ)
Q1: What makes Gluconolactone a “second-generation AHA”?
A: Unlike first-generation AHAs (like glycolic acid), gluconolactone is a polyhydroxy acid (PHA) with a larger molecular structure. This limits rapid skin penetration, resulting in a gentler, more gradual exfoliation and significantly lower irritation. Additionally, the presence of multiple hydrophilic groups provides enhanced moisturizing properties, making it more hydrating than traditional AHAs.
Q2: How does Gluconolactone compare to Glycolic Acid?
A: Gluconolactone is much gentler and less irritating than glycolic acid. While glycolic acid penetrates deeply and quickly (causing potential stinging or redness), gluconolactone’s larger molecular structure slows down penetration. A study noted only a 6% decrease in dermal penetration compared to glycolic acid, making it as effective as AHAs but less sensitizing. It is the preferred choice for sensitive skin types.
Q3: Is Gluconolactone suitable for sensitive skin?
A: Yes. This is one of its greatest advantages. Gluconolactone is specifically designed to be gentle, making it suitable for sensitive skin and even skin prone to rosacea. Unlike glycolic acid, it causes minimal stinging or redness, making it an ideal active for sensitive formulations.
Q4: Can Gluconolactone be combined with other active ingredients?
A: Yes. Clinical studies have shown it works effectively in combination with retinoic acid for acne treatment and with retinyl acetate for anti-aging benefits. It also pairs well with other humectants and skin conditioners. Its gentle nature makes it a versatile component in complex formulations.