Soothing Anti-Inflammatory Agent, The Ideal Choice for Acne-Prone and Sensitive Skin

ZLEY® GS – Glycol Salicylate (CAS 87-28-5):

Soothing Anti-Inflammatory Agent, The Ideal Choice for Acne-Prone and Sensitive Skin

Product Overview

ZLEY® GS (Glycol Salicylate) is a skin conditioning agent with anti‑inflammatory and analgesic properties. As a non‑steroidal anti‑inflammatory agent (NSAID) and topical analgesic, it is used to relieve mild to moderate muscle and joint pain.

As a salicylic acid derivative, its modified structure addresses the instability and irritation commonly associated with salicylic acid while increasing its lipid solubility, enabling better skin absorption. It helps improve skin appearance by targeting wrinkles, acne, and pigmentation issues. It also functions as a soothing humectant, photostabilizer, and mild sunscreen agent with minimal skin irritation.

ZLEY® is a professional supplier of Glycol Salicylate (CAS 87-28-5), providing stable quality, technical support, and global delivery services covering over 60 countries.

ZLEY® GS Product Information

Formulation Processing Guidelines

• Emulsion Systems: Add at low temperature after emulsification and mix thoroughly.
• Anhydrous Oil Systems: Add directly to the oil phase. Dissolves well in polar oils; dissolution may be slower in vegetable oils.
• Aqueous Systems:
• CO-40 : Glycol Salicylate = 1:2 – Mix thoroughly first, then add to water.
• Dipropylene Glycol : Glycol Salicylate = 20:1 – Mix thoroughly first, then add to water.
• Butylene Glycol : Glycol Salicylate = 28:1 – Mix thoroughly first, then add to water.
• Propylene Glycol : Glycol Salicylate = 30:1 – Mix thoroughly first, then add to water.

Note: Avoid prolonged heating at high temperatures!

Is ZLEY® GS Safe?

Yes. Based on data from marketed products, Glycol Salicylate is safely used in leave-on facial products at concentrations up to 0.5% . Under normal, reasonable, and foreseeable conditions of use, it does not pose a risk to human health.

Product Applications

ZLEY® GS primarily functions as an anti-inflammatory, soothing, antibacterial, and anti-acne agent in cosmetics and skincare products.

Why Source ZLEY® GS from ZLEY®?

With over 20 years of dedicated experience, ZLEY® has evolved into a modern enterprise integrating research, production, quality control, and sales. We are committed to providing the highest quality personal care raw materials, semi-finished products, and customized formulation solutions to meet diverse customer needs. Our global delivery network ensures reliable service to customers in over 60 countries.

Email: [email protected]

What Technical Support Can You Expect?

As a specialized supplier, ZLEY® offers value beyond the product itself:

• Formulation Support: Basic formulation recommendations, combination suggestions, and processing guidance
• Regulatory Consulting: Assistance with interpreting compliance requirements for target markets
• Quality Assurance: Consistent quality, competitive pricing, and reliable global logistics
• Market Intelligence: Latest market trends and ingredient application insights

ZLEY® GS – Frequently Asked Questions (FAQ)

Q1: What is Glycol Salicylate, and how is it different from Salicylic Acid?

A: Glycol Salicylate is a salicylic acid derivative formed by esterifying salicylic acid with ethylene glycol. Unlike salicylic acid, which is a BHA (beta-hydroxy acid) with strong exfoliating and potentially irritating effects, Glycol Salicylate is milder and less irritating, and has higher lipid solubility, allowing for better skin penetration. It works as a prodrug, releasing salicylic acid upon enzymatic hydrolysis in the skin, providing anti-inflammatory and soothing benefits with reduced irritation.

Q2: What are the key benefits of ZLEY® GS?

A: ZLEY® GS offers a wide range of skin benefits:

• Soothing & Anti-inflammatory: Reduces redness, irritation, and discomfort associated with acne and sensitive skin.
• Acne & Blemish Improvement: Helps improve acne, blackheads, and blemishes.
• Skin Conditioning: Improves skin appearance, addressing wrinkles and uneven pigmentation.
• Photostabilizer & Sunscreen: Provides photostabilizing properties and contributes to UV protection.

Q3: Is ZLEY® GS suitable for sensitive and acne-prone skin?

A: Yes. Glycol Salicylate is specifically valued for its gentle, low-irritating nature compared to salicylic acid. It provides effective anti-inflammatory and antibacterial benefits while being less likely to cause the stinging, redness, or peeling associated with higher concentrations of salicylic acid. This makes it an ideal choice for acne-prone and sensitive skin formulations.

Q4: What is the recommended usage level for ZLEY® GS?

A: The recommended usage range is 0.1%–1.0%. Safety assessments based on marketed product data confirm that Glycol Salicylate is safely used in leave-on facial products at concentrations up to 0.5%. Formulators should adjust within this range based on product type and target efficacy.

Q5: How should ZLEY® GS be incorporated into formulations?

A: ZLEY® GS is insoluble in water but soluble in oils and polyols.

For emulsions: Add at low temperature after emulsification.
For anhydrous systems: Add directly to the oil phase.
For aqueous systems: Pre-solubilize with appropriate solubilizers or polyols before adding to water.

Prolonged heating should be avoided to maintain stability.