{"id":9652,"date":"2026-07-29T15:41:14","date_gmt":"2026-07-29T07:41:14","guid":{"rendered":"https:\/\/www.zleygroup.com\/?p=9652"},"modified":"2026-07-29T15:41:14","modified_gmt":"2026-07-29T07:41:14","slug":"%d0%be%d0%b4%d0%be%d0%b1%d1%80%d0%b5%d0%bd%d0%bd%d0%be%d0%b5-fda-%d0%b1%d0%b5%d0%b7%d1%80%d0%b5%d1%86%d0%b5%d0%bf%d1%82%d1%83%d1%80%d0%bd%d0%be%d0%b5-%d1%81%d1%80%d0%b5%d0%b4%d1%81%d1%82%d0%b2%d0%be","status":"publish","type":"post","link":"https:\/\/www.zleygroup.com\/ru\/fda-approved-otc-acne-fighting-agent\/","title":{"rendered":"\u041e\u0434\u043e\u0431\u0440\u0435\u043d\u043d\u043e\u0435 FDA \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043f\u0442\u0443\u0440\u043d\u043e\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043e \u0434\u043b\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0430\u043a\u043d\u0435"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>ZLEY\u00ae RA \u2013 Resorcinol Acetate (CAS 102-29-4): <\/strong><strong><\/strong><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>FDA-Approved OTC Acne-Fighting Agent<\/strong><strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"680\" height=\"615\" src=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5.png\" alt=\"\" class=\"wp-image-9653\" title=\"\" srcset=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5.png 680w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5-300x271.png 300w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5-13x12.png 13w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5-600x543.png 600w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-5-64x58.png 64w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><figcaption><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Product Overview<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">ZLEY\u00ae RA (INCI: Resorcinol Acetate), also known as&nbsp;<strong>Acetylresorcinol<\/strong>&nbsp;or&nbsp;<strong>Euresol<\/strong>, is a resorcinol derivative. It is recognized by the U.S. FDA as an approved active ingredient in over-the-counter (OTC) topical acne drug products and is listed in the U.S. OTC Drug Monograph for acne treatment<a href=\"https:\/\/drugs.ncats.io\/drug\/YL6O37RD1S\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>. It offers antibacterial, post-acne spot-fading, and keratolytic properties. It is used to treat acne, seborrheic dermatitis, and tinea pedis, and is also effective as a mild, non-irritating anti-dandruff agent for the scalp.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ZLEY\u00ae is a professional supplier of Resorcinol Acetate (CAS 102-29-4), providing stable quality, technical support, and global delivery covering over 60 countries.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ZLEY\u00ae RA Product Information<\/strong><strong><\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Parameter<\/td><td>Specification<\/td><\/tr><tr><td><strong>INCI Name<\/strong><\/td><td>Resorcinol Acetate<\/td><\/tr><tr><td><strong>CAS Number<\/strong><\/td><td>102-29-4<\/td><\/tr><tr><td><strong>Appearance<\/strong><\/td><td>Colorless to pale yellow viscous liquid, characteristic odor<\/td><\/tr><tr><td><strong>Recommended Usage<\/strong><\/td><td>0.1 \u2013 1.0% [Note: Up to 3% in the U.S. and Canada under OTC drug rules]<\/td><\/tr><tr><td><strong>Solubility<\/strong><\/td><td>Insoluble in water; soluble in alcohol and oils<\/td><\/tr><tr><td><strong>Suitable Formulations<\/strong><\/td><td>Anti-acne products, anti-dandruff products<\/td><\/tr><tr><td><strong>Processing<\/strong><\/td><td><strong>Emulsion systems:<\/strong>&nbsp;Add at low temperature after emulsification and mix thoroughly.<br><strong>Anhydrous oil systems:<\/strong>&nbsp;Add directly to the oil phase and dissolve.<\/td><\/tr><tr><td><strong>Thickener Compatibility<\/strong><\/td><td>Suitable for ion-tolerant systems.<\/td><\/tr><tr><td><strong>Storage Notes<\/strong><\/td><td>Avoid prolonged heating; store in light-protected conditions.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Is ZLEY\u00ae RA Safe?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes. According to the U.S. FDA OTC Drug Monograph,&nbsp;<strong>Resorcinol Monoacetate (3%)<\/strong>&nbsp;is recognized as safe and effective (GRASE) for use in over-the-counter topical acne drug products when formulated according to established conditions&nbsp;<a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/www.federalregister.gov\/documents\/full_text\/xml\/2010\/03\/04\/2010-4424.xml\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>. Safety assessments based on China&#8217;s &#8220;Information on the Use of Ingredients in Marketed Products&#8221; confirm that up to 1% in leave-on products is safe&nbsp;<a href=\"http:\/\/www.weijinci.cn\/zhuangqiyi\/yss\/inci\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"http:\/\/www.hzpwjc.cn\/apgj\/inci2021\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Product Applications<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In cosmetics and skincare, ZLEY\u00ae RA functions primarily as a&nbsp;<strong>skin conditioning agent<\/strong>. Its key applications include<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Anti-acne products<\/strong>\u00a0\u2013 Reduces blemishes, pimples, and blackheads\u00a0<a href=\"https:\/\/drugs.ncats.io\/drug\/YL6O37RD1S\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><\/li>\n\n\n\n<li><strong>Anti-dandruff products<\/strong>\u00a0\u2013 Mild, non-irritating scalp treatment<\/li>\n\n\n\n<li><strong>Seborrheic dermatitis treatments<\/strong><\/li>\n\n\n\n<li><strong>Tinea pedis (athlete&#8217;s foot) treatments<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Why Source ZLEY\u00ae RA from ZLEY\u00ae?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">With over 20 years of dedicated experience, ZLEY\u00ae has evolved into a modern enterprise integrating research, production, quality control, and sales. We are committed to providing the highest quality personal care raw materials, semi-finished products, and customized formulation solutions to meet diverse customer needs. Our global delivery network ensures reliable service to customers in over 60 countries.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Email:<\/strong>&nbsp;<a href=\"mailto:services@zleygroup.com\"><u>services@zleygroup.com<\/u><\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>What Technical Support Can You Expect?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">As a specialized supplier, ZLEY\u00ae offers value beyond the product itself:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Formulation Support:<\/strong>\u00a0Basic formulation recommendations, combination suggestions, and processing guidance<\/li>\n\n\n\n<li><strong>Regulatory Consulting:<\/strong>\u00a0Assistance with interpreting compliance requirements for target markets (U.S. OTC Monograph, EU regulations, etc.)<\/li>\n\n\n\n<li><strong>Quality Assurance:<\/strong>\u00a0Consistent quality, competitive pricing, and reliable global logistics<\/li>\n\n\n\n<li><strong>Market Intelligence:<\/strong>\u00a0Latest market trends and ingredient application insights<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ZLEY\u00ae RA \u2013 Frequently Asked Questions (FAQ)<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q1: What is the FDA status of Resorcinol Acetate?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: Resorcinol Acetate is listed as a Category I (GRASE \u2013 Generally Recognized as Safe and Effective) active ingredient for OTC topical acne drug products in the U.S. FDA regulations (21 CFR \u00a7 333.310). The monograph permits up to&nbsp;<strong>3% Resorcinol Monoacetate (chemically equivalent to Resorcinol Acetate)<\/strong>&nbsp;in OTC acne products<a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/www.federalregister.gov\/documents\/full_text\/xml\/2010\/03\/04\/2010-4424.xml\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>. It is also included in China&#8217;s &#8220;Inventory of Existing Cosmetic Ingredients (2021 Edition)&#8221;<a href=\"http:\/\/www.weijinci.cn\/zhuangqiyi\/yss\/inci\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"http:\/\/www.hzpwjc.cn\/apgj\/inci2021\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q2: How does Resorcinol Acetate differ from Resorcinol?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: Resorcinol Acetate is the esterified (acetylated) form of resorcinol. This structural modification reduces reactivity and irritation potential while maintaining effective acne-fighting properties, making it more suitable for controlled formulation use<a href=\"https:\/\/www.zleygroup.com\/products\/resorcinol-acetate\/\"><\/a>. Resorcinol itself is regulated in the EU for hair dye applications and cannot be used in leave-on cosmetics<a href=\"#2#2\"><\/a><a href=\"#2#1\"><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q3: What are the regulatory concentration limits for different markets?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A:The concentration limits vary by market:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>U.S. (OTC Drug):<\/strong>\u00a0Up to\u00a0<strong>3%<\/strong>\u00a0<a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><\/li>\n\n\n\n<li><strong>Canada:<\/strong>\u00a0Up to\u00a0<strong>3%<\/strong>\u00a0(permitted in OTC acne products).<\/li>\n\n\n\n<li><strong>China (Cosmetics):<\/strong>\u00a0Maximum historical use in leave-on products is\u00a0<strong>1%<\/strong>\u00a0based on marketed product data.\u00a0<a href=\"http:\/\/www.weijinci.cn\/zhuangqiyi\/yss\/inci\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"http:\/\/www.hzpwjc.cn\/apgj\/inci2021\/07728.html\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><\/li>\n\n\n\n<li><strong>EU:<\/strong>\u00a0Resorcinol Acetate is not specifically listed in Annex V; formulators should verify compliance on a product-by-product basis<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q<\/strong><strong>4<\/strong><strong>: Is ZLEY\u00ae RA suitable for sensitive skin?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: Resorcinol Acetate is generally considered&nbsp;<strong>milder than free resorcinol<\/strong>&nbsp;due to its esterified structure<a href=\"https:\/\/www.zleygroup.com\/products\/resorcinol-acetate\/\"><\/a>. However, individual skin tolerance may vary. For sensitive skin formulations, we recommend starting at lower concentrations (0.1\u20130.5%) and conducting patch testing. As with all OTC drug ingredients in the U.S., appropriate warnings and directions must be included on product labeling<a href=\"https:\/\/chanrobles.com\/usa\/uslaws\/cfr\/title21\/21-5.0.1.1.12.4.php\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/www.federalregister.gov\/documents\/full_text\/xml\/2010\/03\/04\/2010-4424.xml\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ZLEY\u00ae RA \u2013 Resorcinol Acetate (CAS 102-29-4): FDA-Approved OTC Acne-Fighting Agent Product Overview ZLEY\u00ae RA (INCI: Resorcinol Acetate), also known [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9653,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[69],"tags":[],"class_list":["post-9652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-active-ingredients"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/posts\/9652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/comments?post=9652"}],"version-history":[{"count":0,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/posts\/9652\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/media\/9653"}],"wp:attachment":[{"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/media?parent=9652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/categories?post=9652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zleygroup.com\/ru\/wp-json\/wp\/v2\/tags?post=9652"}],"curies":[{"name":"WP","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}