1,4:3,6-Dianhydro-D-glucitol (Isosorbide) is a bio-based rigid diol derived from glucose, widely used to enhance the mechanical strength, thermal stability, and sustainability of advanced formulations. Known for its unique bicyclic structure, it improves rigidity and heat resistance when incorporated into polymers, resins, coatings, and specialty chemical systems, while maintaining excellent compatibility with other formulation components. As a renewable alternative to petroleum-based diols, Isosorbide supports the development of high-performance and environmentally responsible materials, making it ideal for applications requiring durability, stability, and bio-based content.
1,4:3,6-Dianhydro-D-glucitol
| INCI: | Isosorbide |
| Properties: | Bio-based rigid diol with high thermal stability and excellent chemical resistance. Enhances mechanical strength, rigidity, and heat resistance in formulations while supporting sustainable and renewable material development. |
| Appearance: | White crystalline powder |
| Recommended dosage: | 1.0–30.0% |
| Solubility: | Soluble in water and polar solvents |
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FAQs
What is 1,4:3,6-Dianhydro-D-glucitol?
1,4:3,6-Dianhydro-D-glucitol, commonly known as isosorbide, is a bio-based diol obtained from sorbitol through a double dehydration process. It is widely used in pharmaceuticals, polymers, and cosmetic formulations due to its stability, rigidity, and renewable origin.
Is isosorbide the same as sorbitol?
No, isosorbide is derived from sorbitol but they are not the same substance. Sorbitol is a sugar alcohol, while isosorbide is a bicyclic diol formed by intramolecular dehydration, giving it different chemical and functional properties.
What is isosorbide used for?
Isosorbide is commonly used as an excipient or functional ingredient in pharmaceutical formulations, as a bio-based monomer in polymers and resins, and as a solvent or stabilizing agent in cosmetic products.
Is isosorbide safe for cosmetic and pharmaceutical use?
Isosorbide is generally considered safe when used in accordance with applicable regulations and recommended usage levels. It is widely compliant with USP, EP, and cosmetic regulatory standards.
Is isosorbide water soluble?
Yes, isosorbide is highly soluble in water and shows good compatibility with various polar solvents, making it easy to incorporate into aqueous and semi-aqueous formulations.
What is 1,4:3,6-Dianhydro-D-glucitol?
1,4:3,6-Dianhydro-D-glucitol, commonly known as isosorbide, is a bio-based diol obtained from sorbitol through a double dehydration process. It is widely used in pharmaceuticals, polymers, and cosmetic formulations due to its stability, rigidity, and renewable origin.
Is isosorbide the same as sorbitol?
No, isosorbide is derived from sorbitol but they are not the same substance. Sorbitol is a sugar alcohol, while isosorbide is a bicyclic diol formed by intramolecular dehydration, giving it different chemical and functional properties.
What is isosorbide used for?
Isosorbide is commonly used as an excipient or functional ingredient in pharmaceutical formulations, as a bio-based monomer in polymers and resins, and as a solvent or stabilizing agent in cosmetic products.
Is isosorbide safe for cosmetic and pharmaceutical use?
Isosorbide is generally considered safe when used in accordance with applicable regulations and recommended usage levels. It is widely compliant with USP, EP, and cosmetic regulatory standards.
Is isosorbide water soluble?
Yes, isosorbide is highly soluble in water and shows good compatibility with various polar solvents, making it easy to incorporate into aqueous and semi-aqueous formulations.
Also Known As
Isosorbide
1,4:3,6-Dianhydro-D-glucitol
1,4:3,6-Dianhydrosorbitol
Dianhydro sorbitol
Isosorbide (USP / EP)
Isosorbide anhydrous
Isosorbide
1,4:3,6-Dianhydro-D-glucitol
1,4:3,6-Dianhydrosorbitol
Dianhydro sorbitol
Isosorbide (USP / EP)
Isosorbide anhydrous