{"id":9660,"date":"2026-08-03T12:15:28","date_gmt":"2026-08-03T04:15:28","guid":{"rendered":"https:\/\/www.zleygroup.com\/?p=9660"},"modified":"2026-08-03T12:30:39","modified_gmt":"2026-08-03T04:30:39","slug":"liposomal-ceramide-raw-material-supplier-guide","status":"publish","type":"post","link":"https:\/\/www.zleygroup.com\/ja\/liposomal-ceramide-raw-material-supplier-guide\/","title":{"rendered":"\u30bb\u30e9\u30df\u30c9\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u306e\u9069\u683c\u6027\u8a55\u4fa1\uff1a\u30ea\u30dd\u30bd\u30fc\u30e0\u578b\u30bb\u30e9\u30df\u30c9\u539f\u6599\u306e\u8a55\u4fa1"},"content":{"rendered":"<style>\nbody.postid-9660 .zley-post-featured{display:none!important}\nbody.postid-9660 .zley-post-content img{height:auto}\n@media(max-width:767px){\nbody.postid-9660 .mystickyelements-fixed{display:none!important}\nbody.postid-9660 .zley-post-layout{grid-template-columns:minmax(0,1fr)!important}\nbody.postid-9660 .zley-post-content{min-width:0!important;width:100%!important;max-width:100%!important}\nbody.postid-9660 .wp-block-table{display:block;max-width:100%;overflow-x:auto;-webkit-overflow-scrolling:touch}\nbody.postid-9660 figure.wp-block-image{width:100%!important;max-width:100%!important}\nbody.postid-9660 .zley-post-content p,body.postid-9660 .zley-post-content h2,body.postid-9660 .zley-post-content h3{overflow-wrap:anywhere}\n}\n<\/style>\n\n\n\n<p class=\"wp-block-paragraph\">Finding a ceramide supplier is easy. Qualifying a grade that will survive scale-up is harder. The purchasing decision is not only about Ceramide NP price or the number shown on a sales sheet. Ceramides are highly lipophilic, and their behavior depends on the carrier system, the other barrier lipids, the order of addition, and the final emulsion.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For teams developing barrier creams, lotions, or milky serums, a ready-to-use <strong>liposomal ceramide raw material<\/strong> can remove part of the pre-dispersion work. It does not remove the need to qualify the dispersion itself. This guide uses <a href=\"https:\/\/www.zleygroup.com\/products\/zleypkg201\/\">ZLEY PKG201<\/a> as a concrete example and shows what a formulator or buyer should verify before approving a sample.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd.jpg\" alt=\"ZLEY PKG201 \u5316\u7ca7\u54c1\u7528\u30d0\u30ea\u30a2\u51e6\u65b9\u5411\u3051\u30ea\u30dd\u30bd\u30fc\u30e0\u578b\u30bb\u30e9\u30df\u30c9\u539f\u6599\" class=\"wp-image-9646\" title=\"\" srcset=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd.jpg 800w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-300x300.jpg 300w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-250x250.jpg 250w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-768x768.jpg 768w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-12x12.jpg 12w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-600x600.jpg 600w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-100x100.jpg 100w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/751715482483c45194f2d903263b94fd-64x64.jpg 64w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">PKG201 at a glance<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody>\n<tr><th>Buyer question<\/th><th>Published grade information<\/th><\/tr>\n<tr><td>Commercial form<\/td><td>Milky-white viscous liquid; a multi-component ceramide dispersion rather than a neat ceramide powder<\/td><\/tr>\n<tr><td>Published composition<\/td><td>Glycerin, water, octyldodecanol, phospholipids, hydrogenated phosphatidylcholine, cholesterol, Ceramide NP, tocopherol, and sunflower seed oil<\/td><\/tr>\n<tr><td>Supplier starting use level<\/td><td>1-5% of the finished dispersion<\/td><\/tr>\n<tr><td>Handling<\/td><td>Dispersible in water; the product page also lists compatibility with glycols and alcohols<\/td><\/tr>\n<tr><td>Best first applications<\/td><td>Opaque or milky creams, lotions, and emulsion serums positioned for moisturization and barrier support<\/td><\/tr>\n<tr><td>Critical item not stated publicly<\/td><td>Ceramide assay, particle-size specification, pH window, preservative system, and validated process-temperature limit<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91cd\u8981\uff1a<\/strong> the 1-5% figure is the recommended addition level for the complete dispersion. It is not a claim that the final formula contains 1-5% pure Ceramide NP. Ask for the current signed TDS and composition statement before calculating an active-dose claim or finalizing an ingredient list.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why the delivery system matters more than a headline percentage<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A ceramide does not work in isolation from its vehicle. In a human barrier-recovery study, an emulsion combining ceramides with phytosphingosine, cholesterol, and a free fatty acid accelerated recovery after surfactant damage more effectively than the tested ceramide-only mixture. The practical lesson is formulation-specific: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12482041\/\" target=\"_blank\" rel=\"noopener nofollow\">the organization and ratio of barrier lipids matter<\/a>, not just whether &#8220;ceramide&#8221; appears on the label.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A separate 2021 formulation study developed stable liposomes containing ceramides 3 and 6 together with cholesterol and stearic acid. The researchers evaluated particle size and polydispersity rather than accepting &#8220;liposomal&#8221; as a self-proving claim. That is the right procurement mindset for any <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33486027\/\" target=\"_blank\" rel=\"noopener nofollow\">ceramide liposome system<\/a>.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>These publications explain useful formulation principles. They are not performance data for PKG201, and they should not be presented as clinical proof for a finished product made with this grade.<\/p><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">A practical first-lab protocol<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Build and homogenize the base first.<\/strong> Complete the emulsion and its primary high-shear step before introducing the ceramide dispersion.<\/li>\n<li><strong>Add during cool-down.<\/strong> For an initial screen, add below 40 C under moderate sweep unless the current supplier TDS gives a validated alternative. Treat this as a conservative development starting point, not a guaranteed manufacturing limit.<\/li>\n<li><strong>Pre-dilute only when needed.<\/strong> If direct addition creates local streaks or lumps, pre-disperse PKG201 in a small portion of the cool aqueous phase or a compatible glycol from the formula.<\/li>\n<li><strong>Run a 1%, 3%, and 5% ladder.<\/strong> Keep the rest of the vehicle constant. This separates a genuine dose response from changes caused by oil phase, emulsifier, or humectant adjustments.<\/li>\n<li><strong>Avoid automatic post-addition high shear.<\/strong> If high shear is required for appearance, compare particle size or at least microscopy before and after processing. A smooth-looking batch does not prove that the original vesicle structure remains intact.<\/li>\n<li><strong>Record 24- and 48-hour values.<\/strong> Check pH, viscosity, color, odor, uniformity, and centrifuge behavior after the system has equilibrated.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">The main compatibility risks are high electrolyte load, aggressive surfactants, high alcohol content, an extreme pH, and repeated heat exposure. A small design-of-experiments screen is more useful than one &#8220;successful&#8221; bench batch. Include the blank vehicle and compare it with each PKG201 level.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Where this grade fits, and where it does not<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Good starting projects<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Barrier-support face creams and body lotions<\/li>\n<li>Milky serums and light emulsions for dry or sensitive-feeling skin<\/li>\n<li>After-sun moisturizers and formulas designed to support skin comfort<\/li>\n<li>Multi-active systems where easier handling is more important than a single-INCI raw material<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Poor starting projects<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Water-clear gels, because the milky dispersion can introduce haze<\/li>\n<li>Anhydrous oils or balms, because the commercial grade contains water and glycerin<\/li>\n<li>High-alcohol formats without a dedicated compatibility study<\/li>\n<li>Projects that require a high-assay, single-component Ceramide NP powder<\/li>\n<li>Finished-product clinical claims that are not supported by testing on the final formula<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">For a project that needs a water-soluble stress-protection active rather than a barrier-lipid dispersion, a material such as <a href=\"https:\/\/www.zleygroup.com\/products\/zley-ectoin\/\">ZLEY Ectoin<\/a> performs a different formulation job. It should not be treated as a direct substitute for ceramide.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Supplier qualification before the purchase order<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A serious ceramide supplier should be able to answer the following questions with documents, not only marketing copy:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Identity:<\/strong> What is the exact current INCI list, and does it match the label statement for every target market?<\/li>\n<li><strong>Active content:<\/strong> What is the Ceramide NP assay in the supplied dispersion, what method is used, and what is the release range?<\/li>\n<li><strong>Delivery-system control:<\/strong> Is particle size a release specification? If so, request the mean size, distribution method, PDI limit, and data from at least three lots.<\/li>\n<li><strong>Microbiology:<\/strong> What are the microbial limits and preservative components? A water-containing raw material must be included in the finished formula&#8217;s challenge-test strategy.<\/li>\n<li><strong>\u5b89\u5b9a\u6027\uff1a<\/strong> What shelf life, storage temperature, light protection, and freeze-thaw limits are supported?<\/li>\n<li><strong>Traceability:<\/strong> Request a batch COA, SDS, country of origin, manufacturing-flow summary, allergen statement, and relevant GMO or animal-origin declarations.<\/li>\n<li><strong>Regulatory status:<\/strong> Confirm market-specific inventory status and claims language. The <a href=\"https:\/\/cir-safety.org\/supplementaldoc\/safety-assessment-ceramides-used-cosmetics\" target=\"_blank\" rel=\"noopener nofollow\">CIR\u306e\u5b89\u5168\u6027\u8a55\u4fa1<\/a> covers multiple cosmetic ceramides under reported practices of use, but it is not a substitute for regional compliance review of the complete grade and finished product.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Stability work that should happen before scale-up<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">At minimum, compare the blank and selected PKG201 prototypes at 4 C, room temperature, and 40-45 C, plus freeze-thaw and centrifuge screens. Track pH, viscosity, color, odor, separation, and microscopy. If the liposomal structure is part of the technical or marketing rationale, add particle-size and PDI measurements at initial, intermediate, and final checkpoints. Complete preservative efficacy testing on the final formula; supplier microbiological limits do not predict finished-product protection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Agree the incoming specification before the pilot order. Appearance, odor, pH, active assay, microbial limits, and any particle-size criterion should have written acceptance ranges. A COA with only &#8220;conforms&#8221; is weak if the parameter is important to formulation performance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bottom line for formulation buyers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PKG201 is a credible sample candidate when the project needs an easy-to-handle, water-dispersible ceramide complex for an opaque emulsion. It is probably the wrong starting material for a clear gel, an anhydrous product, or a brief that requires a single high-assay ceramide powder. Start with the 1%, 3%, and 5% ladder, protect the dispersion from unnecessary post-addition shear, and do not approve the purchase order until the active assay and delivery-system controls are documented.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Review the <a href=\"https:\/\/www.zleygroup.com\/products\/zleypkg201\/\">PKG201 product page<\/a>, this <a href=\"https:\/\/www.zleygroup.com\/the-all-round-champion-guardian-of-the-skin-barrier\/\">skin barrier technical overview<\/a>, and a related example of <a href=\"https:\/\/www.zleygroup.com\/advanced-cyclodextrin-molecular-encapsulation-technology-maximizing-efficacy-while-minimizing-irritation\/\">cyclodextrin molecular encapsulation<\/a> when comparing delivery formats.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Buyer FAQ<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Is 1-5% the pure Ceramide NP dosage?<\/h3>\n\n\n<p class=\"wp-block-paragraph\">No. It is the supplier&#8217;s recommended use level for the complete PKG201 dispersion. Calculate pure-ceramide exposure only from a documented assay.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can PKG201 be used in a clear serum?<\/h3>\n\n\n<p class=\"wp-block-paragraph\">It is not the first choice. The raw material is milky-white and may create haze. Use a clarity test at the intended dose before promising a transparent appearance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Does a liposomal raw material guarantee better finished-product efficacy?<\/h3>\n\n\n<p class=\"wp-block-paragraph\">No. Delivery-system integrity, dose, base composition, processing, packaging, and use conditions all matter. Support any superiority claim with data on the final formula.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u30ea\u30dd\u30bd\u30fc\u30e0\u578b\u30bb\u30e9\u30df\u30c9\u539f\u6599\u306e\u9078\u5b9a\u306b\u95a2\u3059\u308b\u30d0\u30a4\u30e4\u30fc\u5411\u3051\u30ac\u30a4\u30c9\uff1a\u7d44\u6210\u30011-5%\u306e\u8a66\u9a13\u7bc4\u56f2\u3001\u52a0\u5de5\u3001\u5b89\u5b9a\u6027\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u304a\u3088\u3073\u30d0\u30ea\u30a2\u88fd\u5264\u5411\u3051\u306e\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u6587\u66f8\u3002.<\/p>","protected":false},"author":1,"featured_media":9646,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[69,70],"tags":[],"class_list":["post-9660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-active-ingredients","category-cosmetic-formulation"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/posts\/9660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/comments?post=9660"}],"version-history":[{"count":0,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/posts\/9660\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/media\/9646"}],"wp:attachment":[{"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/media?parent=9660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/categories?post=9660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zleygroup.com\/ja\/wp-json\/wp\/v2\/tags?post=9660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}