医薬品グレードの有効成分 – 鎮静作用、かゆみ止め、抗菌作用

ZLEY® PAE – Paeonol (CAS 552-41-0):

 医薬品グレードの有効成分 – 鎮静作用、かゆみ止め、抗菌作用

製品概要

ZLEY® PAE (Paeonol), also known as Peonol または 2-hydroxy-4-methoxyacetophenone, is an active monomer compound extracted from the root bark of the peony plant (Paeonia suffruticosa) or the dried roots of Cynanchum paniculatum. As a small-molecule phenolic compound, it offers a unique combination of antibacterial, anti-inflammatory, redness-reducing, and antioxidant benefits.

Paeonol has a long history of clinical use in China, with injectable formulations dating back to the 1970s. It is widely used in oral care, hair care, skincare, and cosmetic products. Recent research has also highlighted its potential as an anti-acne adjuvant, with studies showing that it suppresses key inflammatory mediators, scavenges free radicals, and inhibits melanogenesis.

ZLEY® is a professional supplier of Paeonol (CAS 552-41-0), providing stable quality, technical support, and global delivery covering over 60 countries.

ZLEY® PAE Product Information

Is ZLEY® PAE Safe?

Yes. Paeonol is listed in China’s Inventory of Existing Cosmetic Ingredients (2021 Edition) and is considered safe under normal, reasonable, and foreseeable conditions of use. The following maximum historical use concentrations are established based on marketed products:

Note: For rinse-off products, the same concentrations as leave-on apply for each corresponding area. For eye area products, additional eye irritation assessment is required.

作用機序

製品用途

ZLEY® PAE is a versatile skin conditioning agent suitable for a wide range of product categories:

Why Source ZLEY® PAE from ZLEY®?

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• 市場情報： 最新の市場動向と原料の活用に関する知見

ZLEY® PAE – Frequently Asked Questions (FAQ)

Q1: What is Paeonol, and what are its key skincare benefits?

A: Paeonol is a small-molecule phenolic compound extracted from the root bark of the peony plant. It offers a unique combination of antibacterial, anti-inflammatory, antioxidant, and soothing benefits. It exhibits potent activity against bacteria such as S. aureus and E. coli (MIC 62.5 mg/mL), helps calm irritated skin and reduce redness, and inhibits tyrosinase activity to support brightening. Recent studies have also highlighted its efficacy as an anti-acne adjuvant.

Q2: Is ZLEY® PAE suitable for sensitive or acne-prone skin?

A: Yes. Paeonol is known for its soothing and anti-inflammatory properties, making it particularly suitable for sensitive, irritated, or acne-prone skin. Research demonstrates its ability to suppress inflammatory mediators and reduce erythema and swelling, which is beneficial for managing breakouts without the harshness associated with some synthetic actives. Studies have shown it to be an effective component of adjunctive therapy for acne management.

Q3: How should ZLEY® PAE be stored?

A: Store in a 涼しく乾燥した場所 protected from light, in tightly sealed containers. Avoid exposure to high humidity and direct sunlight. Under proper storage conditions, the product maintains excellent stability.

Q4: How should ZLEY® PAE be incorporated into formulations?

A: Paeonol is insoluble in water but soluble in ethanol, oils, and propylene glycol. For optimal incorporation:

• Dissolve in a suitable solvent such as propylene glycol with gentle heating
• Add to the formulation at an appropriate temperature
• Avoid prolonged heating to maintain stability
• For water-based systems, pre-solubilization in an appropriate solvent is required