{"id":9638,"date":"2026-07-22T15:24:27","date_gmt":"2026-07-22T07:24:27","guid":{"rendered":"https:\/\/www.zleygroup.com\/?p=9638"},"modified":"2026-07-22T15:24:27","modified_gmt":"2026-07-22T07:24:27","slug":"nk1r-antagonist-for-soothing-anti-itch-efficacy","status":"publish","type":"post","link":"https:\/\/www.zleygroup.com\/it\/nk1r-antagonist-for-soothing-anti-itch-efficacy\/","title":{"rendered":"Antagonista dell'NK1R per l'efficacia lenitiva e antipruriginosa"},"content":{"rendered":"<h2 class=\"wp-block-heading\"><strong>ZLEY\u00ae HPA \u2013 Hydroxyphenyl Propamidobenzoic Acid (CAS 697235-49-7): <\/strong><strong><\/strong><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Antagonista dell'NK1R per l'efficacia lenitiva e antipruriginosa<\/strong><strong><\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"693\" height=\"615\" src=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4.png\" alt=\"\" class=\"wp-image-9639\" title=\"\" srcset=\"https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4.png 693w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4-300x266.png 300w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4-14x12.png 14w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4-600x532.png 600w, https:\/\/www.zleygroup.com\/wp-content\/uploads\/2026\/07\/\u56fe\u72471-4-64x57.png 64w\" sizes=\"(max-width: 693px) 100vw, 693px\" \/><figcaption><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Panoramica del prodotto<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">ZLEY\u00ae&nbsp;HPA (INCI: Hydroxyphenyl Propamidobenzoic Acid), also known as Dihydroavenanthramide D, is a potent&nbsp;<strong>neurokinin-1 receptor (NK1R) antagonist<\/strong>. By competitively binding to NK1R, it blocks the SP\/NK1R signaling pathway, inhibits mast cell degranulation, and reduces the release of pruritogenic mediators such as histamine. This mechanism provides rapid relief from skin itching and discomfort, delivering effective soothing and anti-itch benefits. ZLEY\u00ae HPA also offers additional benefits,&nbsp;including barrier repair and photoprotection<a href=\"https:\/\/www.ulprospector.com\/en\/asia\/PersonalCare\/Detail\/111978\/4445746\/Zley-Avena-Sativa-Alkaloid?st=20&amp;sl=351564870&amp;crit=SW50ZXJuZXQgU2VhcmNoID4gU2lubyBMaW9uIOS4reeLruWMluWtpiA+IFpsZXkgSG9sZGluZ3MgKFN1emhvdSkgQ28uLCBMdGQg5aaG6I6x5o6n6IKh77yI6IuP5bee77yJ6IKh5Lu95pyJ6ZmQ5YWs5Y+4ID4gSW5ncmVkaWVudHMgPiBQaGVub2xz&amp;ss=2\" rel=\"nofollow noopener\" target=\"_blank\"><\/a><a href=\"https:\/\/www.ul.prospector.com\/en\/na\/PersonalCare\/Detail\/110295\/4445746\/Zley-Avena-Sativa-Alkaloid\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ZLEY\u00ae is a professional supplier of Hydroxyphenyl Propamidobenzoic Acid (CAS 697235-49-7), providing stable quality, technical support, and global delivery covering over 60 countries.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ZLEY\u00ae HPA Product Information<\/strong><strong><\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Parametro<\/td><td>Specifiche<\/td><\/tr><tr><td><strong>Nome INCI<\/strong><\/td><td>Acido idrossifenilpropamidobenzoico<\/td><\/tr><tr><td><strong>Numero CAS<\/strong><\/td><td>697235-49-7<\/td><\/tr><tr><td><strong>Aspetto<\/strong><\/td><td>White to off-white powder<\/td><\/tr><tr><td><strong>Uso consigliato<\/strong><\/td><td>Full-body leave-on \u2264 2%, Eye area leave-on \u2264 2%<\/td><\/tr><tr><td><strong>Solubilit\u00e0<\/strong><\/td><td>Slightly soluble in water; soluble in alcohol<\/td><\/tr><tr><td><strong>Vantaggi principali<\/strong><\/td><td>Soothing &amp; anti-itch, barrier repair, anti-photoaging<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Formulation Guidelines<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For Emulsion Systems:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Pre-disperse in polyols and heat to dissolve<\/li>\n\n\n\n<li>After emulsification, cool the system to 55-60\u00b0C<\/li>\n\n\n\n<li>Add HPA to the formulation and mix thoroughly<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For Non-Emulsion Systems:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dissolve HPA by adding an alkali (e.g., Arginine)<\/li>\n\n\n\n<li>Combine with polyols (recommended \u22655%)<\/li>\n\n\n\n<li>Add to the system<\/li>\n\n\n\n<li>Adjust the final pH using an acidic pH adjuster<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For Thickener Systems:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Compatible with U-series thickeners (U20, U30) and Carbomer<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nota:<\/strong>&nbsp;May cause significant viscosity reduction when used with AVC or SK425<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Is ZLEY\u00ae HPA Safe?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes. ZLEY\u00ae HPA is considered safe under normal, reasonable, and foreseeable conditions of use at concentrations&nbsp;<strong>fino a 2,01 TP3T<\/strong>&nbsp;in both full-body and eye-area leave-on products.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Applicazioni del prodotto<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">ZLEY\u00ae HPA functions as a&nbsp;<strong>agente emolliente<\/strong>&nbsp;with primary benefits in soothing, anti-itch, and anti-allergy applications. It is suitable for a wide range of products:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Topical creams for contact dermatitis, neurodermatitis, xerotic pruritus, and eczema<\/li>\n\n\n\n<li>Antifungal creams (for athlete&#8217;s foot, tinea corporis) with added anti-itch benefits<\/li>\n\n\n\n<li>Baby &amp; children&#8217;s products \u2013 anti-prickly heat creams, baby eczema balms, insect bite care<\/li>\n\n\n\n<li>Anti-dandruff shampoos and intimate care washes<\/li>\n\n\n\n<li>Nasal spray products<\/li>\n\n\n\n<li>Sensitive skin moisturizers and lotions<\/li>\n\n\n\n<li>Post-sun repair products<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Why Source ZLEY\u00ae HPA from ZLEY\u00ae?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Con oltre 20 anni di esperienza nel settore, ZLEY\u00ae si \u00e8 trasformata in un'azienda moderna che integra ricerca, produzione, controllo qualit\u00e0 e vendite. Ci impegniamo a fornire materie prime per la cura della persona, semilavorati e soluzioni di formulazione personalizzate della massima qualit\u00e0, per soddisfare le diverse esigenze dei clienti. La nostra rete di distribuzione globale garantisce un servizio affidabile ai clienti in oltre 60 paesi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>E-mail:<\/strong>&nbsp;<a href=\"mailto:services@zleygroup.com\"><u>services@zleygroup.com<\/u><\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Che tipo di assistenza tecnica puoi aspettarti?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In qualit\u00e0 di fornitore specializzato, ZLEY\u00ae offre un valore che va oltre il prodotto stesso:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Supporto alla formulazione:<\/strong>\u00a0Raccomandazioni di base sulla formulazione, suggerimenti sulle combinazioni e indicazioni sulla lavorazione<\/li>\n\n\n\n<li><strong>Consulenza normativa:<\/strong>\u00a0Assistenza nell'interpretazione dei requisiti di conformit\u00e0 per i mercati di riferimento<\/li>\n\n\n\n<li><strong>Garanzia di qualit\u00e0:<\/strong>\u00a0Qualit\u00e0 costante, prezzi competitivi e una logistica globale affidabile<\/li>\n\n\n\n<li><strong>Informazioni di mercato:<\/strong>\u00a0Ultime tendenze di mercato e approfondimenti sull'utilizzo degli ingredienti<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>ZLEY\u00ae HPA \u2013 Frequently Asked Questions (FAQ)<\/strong><strong><\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q1: What is the mechanism of action for ZLEY\u00ae HPA?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: ZLEY\u00ae HPA is a&nbsp;<strong>neurokinin-1 receptor (NK1R) antagonist<\/strong>. It works by competitively binding to the NK1R, which blocks the substance P\/NK1R signaling pathway. This inhibition prevents mast cell degranulation and reduces the release of itch-inducing mediators, including histamine. This targeted mechanism provides rapid relief from itching and discomfort, addressing the root cause of pruritus rather than just masking symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q2: How does ZLEY\u00ae HPA compare to traditional anti-itch ingredients?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: Traditional anti-itch ingredients often work through broader mechanisms\u2014such as general anti-inflammatory effects or local anesthetics\u2014which can be less targeted or cause side effects. ZLEY\u00ae HPA&#8217;s mechanism is&nbsp;<strong>specifically targeted at the NK1R pathway<\/strong>, making it highly effective for pruritus relief while maintaining a favorable safety profile. Additionally, HPA provides&nbsp;<strong>barrier repair and anti-photoaging benefits<\/strong>&nbsp;beyond just itch relief, offering multiple skin benefits in one ingredient<a href=\"https:\/\/www.ulprospector.com\/en\/asia\/PersonalCare\/Detail\/111978\/4445746\/Zley-Avena-Sativa-Alkaloid?st=20&amp;sl=351564870&amp;crit=SW50ZXJuZXQgU2VhcmNoID4gU2lubyBMaW9uIOS4reeLruWMluWtpiA+IFpsZXkgSG9sZGluZ3MgKFN1emhvdSkgQ28uLCBMdGQg5aaG6I6x5o6n6IKh77yI6IuP5bee77yJ6IKh5Lu95pyJ6ZmQ5YWs5Y+4ID4gSW5ncmVkaWVudHMgPiBQaGVub2xz&amp;ss=2\" rel=\"nofollow noopener\" target=\"_blank\"><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q3: What is the recommended usage level for ZLEY\u00ae HPA?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: The recommended usage level is&nbsp;<strong>\u2264 2,0%<\/strong>&nbsp;for both full-body and eye-area leave-on products. Safety assessments confirm that this concentration is safe under normal, reasonable, and foreseeable conditions of use.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q4: Is ZLEY\u00ae HPA suitable for sensitive skin?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A: Yes. ZLEY\u00ae HPA is specifically known for its&nbsp;<strong>soothing and anti-itch properties<\/strong>, making it highly suitable for sensitive skin formulations, baby products, and post-sun repair products. Its mechanism of action targets the underlying causes of skin irritation, making it particularly beneficial for compromised or reactive skin.<\/p>","protected":false},"excerpt":{"rendered":"<p>ZLEY\u00ae HPA \u2013 Hydroxyphenyl Propamidobenzoic Acid (CAS 697235-49-7): NK1R Antagonist for Soothing &amp; Anti-Itch Efficacy Product Overview ZLEY\u00ae&nbsp;HPA (INCI: Hydroxyphenyl [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9639,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[69],"tags":[],"class_list":["post-9638","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-active-ingredients"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/posts\/9638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/comments?post=9638"}],"version-history":[{"count":0,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/posts\/9638\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/media\/9639"}],"wp:attachment":[{"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/media?parent=9638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/categories?post=9638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zleygroup.com\/it\/wp-json\/wp\/v2\/tags?post=9638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}