ZLEY® Gluconolactone (CAS 90-80-2):
La “AHA de segunda generación”: lo suficientemente suave para la piel sensible
Productos
Gluconolactone, also known as the “second-generation alpha-hydroxy acid (AHA)” is an ester formed by the dehydration of gluconic acid’s carboxyl group with its intramolecular hydroxyl group. It belongs to the class of polyhydroxy acids (PHAs).
Compared to first-generation AHAs (such as glycolic acid and salicylic acid), which penetrate deeply and can be irritating, gluconolactone has a larger molecular weight, resulting in slower, more gradual skin penetration y significantly lower irritation. It works by hydrolyzing to gluconic acid on the skin, reducing the adhesion between corneocytes and promoting the gentle shedding of dead skin cells. Additionally, its four hydrophilic groups provide superior water-binding capacity, delivering excellent moisturizing benefits.
ZLEY® is a professional supplier of Gluconolactone (CAS 90-80-2), providing stable quality, technical support, and global delivery covering over 60 countries.
ZLEY® Gluconolactone Product Information
Is ZLEY® Gluconolactone Safe?
Yes. According to the final report from the U.S. Cosmetic Ingredient Review (CIR), gluconolactone is considered safe for use in cosmetic products at concentrations up to 15% in leave-on products y 0.3% in rinse-off products . The ingredient is listed in China’s “Inventory of Existing Cosmetic Ingredients (2021 Edition)” with a maximum historical use level of 15% in leave-on products . En condiciones normales, razonables y previsibles de uso, no supone ningún riesgo para la salud humana.
Aplicaciones de los productos
Gluconolactone, known as the “second-generation AHA” , is a gentle skincare ingredient offering multiple benefits including moisturizing, exfoliation, and skin barrier enhancement . Its mild nature makes it suitable for sensitive skin and for use in combination with other active ingredients such as retinoic acid .
Key applications include:
Why Source ZLEY® Gluconolactone from ZLEY®?
Con más de 20 años de experiencia dedicada, ZLEY® se ha convertido en una empresa moderna que integra investigación, producción, control de calidad y ventas. Nos comprometemos a ofrecer materias primas para el cuidado personal, productos semiacabados y soluciones de formulación a medida de la máxima calidad para satisfacer las diversas necesidades de nuestros clientes. Nuestra red de distribución global garantiza un servicio fiable a clientes de más de 60 países.
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¿Qué tipo de asistencia técnica puedes esperar?
Como proveedor especializado, ZLEY® ofrece un valor que va más allá del propio producto:
- Soporte de formulación: Recomendaciones básicas sobre formulación, sugerencias de combinaciones y orientaciones sobre el procesamiento
- Consultoría Regulatoria: Asistencia en la interpretación de los requisitos de cumplimiento normativo de los mercados objetivo
- Seguro de calidad: Calidad constante, precios competitivos y una logística global fiable
- Información de mercado: Últimas tendencias del mercado y análisis sobre el uso de ingredientes
ZLEY® Gluconolactone – Frequently Asked Questions (FAQ)
Q1: What makes Gluconolactone a “second-generation AHA”?
A: Unlike first-generation AHAs (like glycolic acid), gluconolactone is a polyhydroxy acid (PHA) with a larger molecular structure. This limits rapid skin penetration, resulting in a gentler, more gradual exfoliation and significantly lower irritation. Additionally, the presence of multiple hydrophilic groups provides enhanced moisturizing properties, making it more hydrating than traditional AHAs.
Q2: How does Gluconolactone compare to Glycolic Acid?
A: Gluconolactone is much gentler and less irritating than glycolic acid. While glycolic acid penetrates deeply and quickly (causing potential stinging or redness), gluconolactone’s larger molecular structure slows down penetration. A study noted only a 6% decrease in dermal penetration compared to glycolic acid, making it as effective as AHAs but less sensitizing. It is the preferred choice for sensitive skin types.
Q3: Is Gluconolactone suitable for sensitive skin?
A: Yes. This is one of its greatest advantages. Gluconolactone is specifically designed to be gentle, making it suitable for sensitive skin and even skin prone to rosacea. Unlike glycolic acid, it causes minimal stinging or redness, making it an ideal active for sensitive formulations.
Q4: Can Gluconolactone be combined with other active ingredients?
A: Yes. Clinical studies have shown it works effectively in combination with retinoic acid for acne treatment and with retinyl acetate for anti-aging benefits. It also pairs well with other humectants and skin conditioners. Its gentle nature makes it a versatile component in complex formulations.