Anti-oxidant & Whitening: 0.5% Coburrhy achieved 24% ROS removal and 17% melanin inhibition in zebrafish embryos.

Anti-oxidant: Coburrhy DPPH clearance rate ↑79% and hydroxyl radicals rate ↑54%

Anti-oxidant: after 5 days, the inhibition rate of peroxidation of linoleic acid ↑57%

Anti-Glycation: the AGEs inhibition rate by 19.10%

Anti-redness & soothing: Coburrhy inflammatory factor TNF-α rate ↓20%, gene expression levels NF-kB ↓59%, and HMGB1 ↓34%

Whitening: α-MSH inhibition rate ↓53%, while the β-catenin gene expression level ↓54%

Whitening: Coburrhy inhibited melanosome transfer in the HaCaT-A375 co-culture system by 56% and 92%

Whitening: Coburrhy inhibited melanin synthesis in B16 cells by 17% and 33%

Clinical Assessment