ZLEY®377PRO – Phenylethyl Resorcinol Liposome-10:
Enhanced Penetration, True Brightening – 1 Bottle Equals 8
Product Overview
ZLEY®377PRO (Phenylethyl Resorcinol Liposome-10) is a skin conditioning agent featuring the powerful brightening active Phenylethyl Resorcinol (also known as “377”) delivered via advanced liposome–targeted delivery technology. This system breaks through the absorption barrier between the active ingredient and the skin, acting like an “elevator” to deliver 377 deep into the basal layer within 8 hours, achieving 8.67 times higher transdermal penetration compared to conventional 377 – delivering the equivalent of 8 bottles in 1.
True brightening – reducing dullness and yellow tones – it promotes the expression of Nrf2 antioxidant factors, enhancing the skin’s antioxidant defense capacity. Inhibits MITF protein expression, downregulates tyrosinase and TRP-2 expression, and suppresses melanin production at the source to improve dull and yellow skin tone.
ZLEY® is a professional supplier of Phenylethyl Resorcinol Liposome-10 (CAS: 7732-18-5, 61788-85-0, 107-88-0, 85-27-8, 8002-43-5, 6920-22-5, 58-95-7), providing stable quality, technical support, and global delivery covering over 60 countries.
ZLEY®377PRO Product Information
| Parameter | Specification |
| INCI Name | Water, PEG-40 Hydrogenated Castor Oil, Butylene Glycol, Phenylethyl Resorcinol, Lecithin, 1,2-Hexanediol, Tocopheryl Acetate |
| CAS Numbers | 7732-18-5, 61788-85-0, 107-88-0, 85-27-8, 8002-43-5, 6920-22-5, 58-95-7 |
| Appearance | Yellow to dark yellow liquid, characteristic odor |
| Recommended Usage | 0.5 – 3.3% |
| Solubility | Alcohol-soluble, water-dispersible |
| pH (1% solution) | 6.44 (Note: 1% 377PRO solution appears as a whitish dispersion) |
| Recommended Formulation pH | 4.0 – 6.0 |
Is ZLEY®377PRO Safe?
Yes. Based on available scientific and regulatory information, ZLEY®377PRO is considered safe for cosmetic use when used as directed. Its safety is supported by multiple factors: the nature of its active ingredient, its advanced liposome delivery system, and clear regulatory guidelines.
Product Applications
In cosmetics and skincare, ZLEY®377PRO functions primarily as a skin conditioning agent. It is suitable for emulsions, creams, gels, and water-based formulations, making it ideal for brightening and spot-correcting products.
Product Development Philosophy
To address the three major challenges of Phenylethyl Resorcinol (“377”) – poor skin penetration, low stability, and poor water solubility – ZLEY®’s R&D team innovatively developed liposome–targeted delivery technology. This technology breaks through the stratum corneum’s “brick-and-mortar” barrier structure, delivering 377 faster, more accurately, and more efficiently to the basal layer. It targets melanocytes directly, inhibiting melanin production at the source. This targeted delivery system significantly enhances the bioavailability and brightening efficacy of the active ingredient.
Why Source ZLEY®377PRO from ZLEY®?
With over 20 years of dedicated experience, ZLEY® has evolved into a modern enterprise integrating R&D, production, quality control, and sales. We are committed to providing the highest quality personal care raw materials, semi-finished products, and customized formulation solutions to meet diverse customer needs. Our global delivery network ensures reliable service to customers in over 60 countries.
Email: [email protected]
What Technical Support Can You Expect?
As a specialized supplier, ZLEY® offers value beyond the product itself:
- Formulation Support: Basic formulation recommendations, combination suggestions, and processing guidance
- Regulatory Consulting: Assistance with interpreting compliance requirements for target markets
- Quality Assurance: Consistent product quality, competitive pricing, and reliable global logistics
- Market Intelligence: Latest market trends and ingredient application insights
Frequently Asked Questions (FAQ)
Q1: What is the liposome delivery technology used in ZLEY®377PRO?
A: The liposome delivery system encapsulates Phenylethyl Resorcinol (“377”) within lipid bilayers, protecting it from degradation while enabling efficient transport across the stratum corneum. This “elevator-like” targeted delivery ensures the active ingredient reaches the basal layer where melanocytes reside, achieving 8.67‑fold higher transdermal penetration than conventional 377.
Q2: What is the recommended usage level?
A: The recommended usage range is 0.5–3.3% . For optimal brightening efficacy, we recommend starting at 1–2% and adjusting based on formulation type and target market requirements.
Q3: What is the difference between ZLEY®377PRO and conventional 377 (Phenylethyl Resorcinol)?
A: Conventional 377 has poor water solubility, low stability, and limited skin penetration. ZLEY®377PRO is a liposome-encapsulated system that solves all three challenges, delivering significantly higher bioavailability and superior brightening results at lower effective concentrations.
Q4: Is ZLEY®377PRO suitable for sensitive skin?
A: The liposome encapsulation provides controlled release of the active ingredient, reducing the potential for irritation compared to conventional 377. However, we recommend compatibility testing for specific formulations targeting sensitive skin.