ZLEY® HPR-10 (CAS: 893412-73-2, 5306-85-4):
Next-Generation Retinoid for Ultimate Anti-Aging Performance
Product Overview
ZLEY® HPR-10 is a high‑concentration, ready‑to‑use, next‑generation retinoid raw material. It contains 10% Hydroxypinacolone Retinoate (HPR) combined with Dimethyl Isosorbide, which acts as a solvent and penetration enhancer. The product is intended for use as a skin conditioning agent in cosmetic formulations.
Product Information
| Parameter | Specification |
| INCI Name | Hydroxypinacolone Retinoate, Dimethyl Isosorbide |
| CAS Numbers | 893412-73-2, 5306-85-4 |
| Appearance | Yellow liquid |
| Recommended Usage | 0.01% – 3.0% |
| Solubility | Oil-soluble; soluble in alcohols |
| Suitable Formulations | Emulsions, creams, serums, oils, and other skincare formats |
Product Applications
In cosmetics and skincare, ZLEY® HPR-10 functions primarily as an anti-aging and anti-wrinkle agent.
Is ZLEY® HPR-10 Safe?
HPR is widely recognized as a gentle option among next-generation retinoids. Compared to traditional retinol, it significantly reduces side effects such as stinging, redness, and peeling, making it suitable for sensitive skin and those who cannot tolerate conventional retinoids. When used within the recommended dosage range, it is safe under normal, reasonable, and foreseeable conditions of use. It is recommended to incorporate soothing ingredients into formulations to further enhance gentleness.
Core Advantages
1. Direct-Acting – No Conversion Required
Unlike traditional retinol, which must first be converted into retinaldehyde and then into retinoic acid, the molecular structure of HPR can directly bind to retinoic acid receptors in the skin. This means:
- Faster onset of action, more direct results
- No dependence on the skin’s enzymatic conversion capacity
- High efficacy even at low usage levels
2. High Stability, Low Irritation
While delivering powerful anti-aging benefits, HPR significantly reduces the irritation associated with traditional vitamin A derivatives:
- Superior photothermal stability compared to conventional retinol
- Resistant to oxidation and discoloration
- Suitable for sensitive skin and retinol-intolerant users
3. Multi-Benefit – One Ingredient, Multiple Functions
| Benefit Category | Mechanism of Action |
| Anti-Wrinkle & Firming | Promotes synthesis of type I and type III procollagen, filling wrinkles and sagging areas |
| Brightening & Spot Correction | Inhibits melanin production; accelerates shedding of melanin-containing keratinocytes |
| Acne Control & Sebum Regulation | Promotes normal keratinocyte differentiation; reduces follicle clogging; inhibits Cutibacterium acnes |
| Anti-Photoaging | Inhibits UV-induced MMP1 and MMP9 activity; reduces collagen fiber damage |
Formulation & Application
- Recommended Usage: 0.01% – 3.0% (adjust based on product positioning and formulation system)
- Processing: Add directly to the oil phase; mix thoroughly at room temperature or low temperature
- Compatibility: Can be used synergistically with antioxidants (e.g., Vitamin E), moisturizing ingredients, and soothing agents
ZLEY® HPR-10 – Frequently Asked Questions (FAQ)
Q1: What is the difference between ZLEY® HPR-10 and conventional Retinol?
A: The core difference lies in the mechanism of action. Conventional retinol requires a two‑step conversion in the skin (retinol → retinaldehyde → retinoic acid) to become active, whereas HPR can directly bind to retinoic acid receptors without any conversion. This delivers three key advantages: faster onset of action, lower irritation, and more stable efficacy. ZLEY® HPR-10 is a ready‑to‑use liquid at 10% concentration for easy formulation.
Q2: What is the recommended usage level for ZLEY® HPR-10, and what product types is it suitable for?
A: The recommended usage range is 0.01%–3.0%. We suggest starting at lower concentrations (0.01%–0.1%) and gradually increasing based on the desired efficacy. It is suitable for various skincare formulations, including anti‑aging serums, anti‑wrinkle creams, brightening and spot‑correcting products, acne and sebum‑control formulas, and eye creams. Its oil‑soluble nature makes it easy to incorporate into emulsions, creams, and oil‑based systems.
Q3: What is the difference between ZLEY® HPR-10 and ZLEY® HPR (powder form)?
A: ZLEY® HPR is pure HPR powder with a recommended usage of 0.01%–0.3%, requiring pre‑dissolution in alcohol. ZLEY® HPR-10, on the other hand, is a liquid pre‑diluted solution containing 10% HPR with Dimethyl Isosorbide as a solvent. It is more convenient to use, can be added directly to the oil phase, and is ideal for formulators seeking both high efficacy and ease of use.
Q4: How can I request samples, technical documentation, and pricing?
Please contact our export team via email:
Email: [email protected]
When inquiring, please include your company details, intended product application, and target market so we can provide the most relevant product recommendations and technical information for your specific needs.